HEMATOPOIESIS AND STEM CELLS Characterization of the TGF-b1 signaling abnormalities in the Gata1 mouse model of myelofibrosis
نویسندگان
چکیده
Department of Medicine, Campus Biomedico, and Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY; Myeloproliferative Disease Research Consortium, New York, NY; Service for Biotechnology and Animal Welfare, Istituto Superiore di Sanità, Rome, Italy; Policlinico San Matteo, Pavia, Italy; Medicine and Aging Science, University of Chieti G. D9Annunzio, Chieti, Italy; and Biostatistics, New York University School of Medicine, New York, NY
منابع مشابه
P-Selectin Sustains Extramedullary Hematopoiesis in the Gata1 low Model of Myelofibrosis.
Splenomegaly is a major manifestation of primary myelofibrosis (PMF) contributing to clinical symptoms and hematologic abnormalities. The spleen from PMF patients contains increased numbers of hematopoietic stem cells (HSC) and megakaryocytes (MK). These MK express high levels of P-selectin (P-sel) that, by triggering neutrophil emperipolesis, may cause TGF-β release and disease progression. Th...
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Idiopathic myelofibrosis (IM) is a disease characterized by marrow fibrosis, abnormal stem/progenitor cell trafficking, and extramedullary hematopoiesis frequently associated with alterations in megakaryocytes (Mks). Mice harboring genetic alterations in either the extrinsic (ectopic thrombopoietin expression, TPO(high) mice) or intrinsic (hypomorphic GATA-1 mutation, GATA-1(low) mice) control ...
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